I get annoyed by the Plone instance that installed using the OS X installer starting automatically. I'm now at the stage of having 5 Plone instances, 3 Zope versions and they all run ZEO which doesn't start up automatically, leaving Zope wedged. Fortunately I only restart the once a month or so when my MacBook freezes or the next BIOS patch comes in. It's fixed by removing: /Library/StartupItems/Plone-2.5. In fact I found a few other things in there I didn't want and removed too.